COMPOSITION:
- Live attenuated virus of avian infectious bursitis, strain Lukert
(intermediate strain): Min 10 3 Max 10 5.5 DIO 50 / dose.
- Excipients 1 dose.
SPECIES CONCERNED:
Chicken species (Hen species (Broilers breeding, flayers).
PHARMACEUTICAL PROPERTIES
The vaccine contains the live attenuated Lukert infectious bursitis virus, which is capable of inducing immunity in vaccinated birds. The vaccine is recommended for the prevention of infectious bursitis, in chickens, laying and breeding hens, from the 14th day of age. The use of this strain, the advantage of which is not cloned, gives the chickens a solid and durable protection which appears 10-14 days after vaccination and can last more than 4 weeks after a single administration. The expected results are a function of several factors, including but not limited to, the storage conditions of the vaccine, its administration, the quality of reconstitution water as well as the sanitary and hygienic state of the farm.
THERAPEUTIC INDICATIONS:
Active immunization of the hen species against avian infectious bursitis (Gumboro disease). The ATLAVAC GUMBORO PLUS vaccine strain is an intermediate plus strain which induces active immunity in chickens from the 14th day of age.
CONTRAINDICATIONS:
Sick birds should be excluded from vaccination.
Avoid vaccinating during the laying period
ADMINISTRATION AND DOSAGE:
Administer a dose of at least 103.0 DIE50 per bird, from the 14th day of age. Route of administration The vaccine is administered orally after reconstitution of the lyophilized vaccine according to the procedures described below.
- The determination of the date of vaccination depends on several factors in particular, the level of maternal antibodies presents in the chicks, the conditions of the breeding and the sanitary situation of the chickens.
Evaluating the level of maternal antibodies is essential for determining the optimal age for vaccination and ensuring good immunization of the birds. For this, serological tests must be carried out on samples taken from the strip to be vaccinated to predict the age of vaccination. In chicks, vaccination can be done on the 14th day as a single injection or with
booster depending on the immune status of the birds. In a flock where the level of antibodies varies between birds, vaccination on the 14th day then booster after 7 days.
In general, the following program can be adopted for chicken vaccination: - Chickens with low levels of maternal antibodies: single vaccination at 14 days of age. - Chickens with high maternal antibody levels: Vaccination on the 14th day of age then a booster vaccination on the 21st day of age to boost immunity since the level of maternal antibodies drops significantly at this age. - Chickens without antibodies (naive breeding): Vaccination on the 14th day of age then a vaccination booster on the 21st day of age.
Method of administration:
Oral route by incorporation into drinking water:
• Administration of the vaccine in drinking water is recommended from the 14th day of age.
• The water to be used for the administration of the vaccine must be free of all traces of sanitizing or disinfectant medication.
• Water troughs and pipes must be cleaned, rinsed well and in sufficient quantity so that all the chickens can drink at the same time.
• Before vaccination, remove the drinking water for 2 to 3 hours to stimulate thirst in chickens.
• The vaccine reconstitution water must be fresh and clean without traces of chlorine, detergent or any other disinfectant.
• The vaccine is used immediately after its reconstitution; it is distributed in the drinkers taking care not to expose it to direct light.
• For better stability of the virus, add skimmed milk to the drinking water (for example 2 to 4g per liter).
• Before reconstituting the vaccine: - Make sure that the water to be used is cold. - Determine the number of doses of vaccine and the amount of water required based on the number of birds to be vaccinated so that the intake lasts one to two hours maximum following the preparation of the vaccine suspension
• Do not divide the contents of a vial when dissolving in the drinking water to avoid mixing errors.
• Open the ampoule under water and completely reconstitute the vaccine. Make sure to rinse the bottle and the cap twice and recover all the contents in the drinking water.
• Add skimmed milk powder to the reconstituted vaccine suspension at a rate of 2 to 4 g per liter.
• Prepare only the volume of vaccine to be administered within two hours of mixing.
• Please ensure that the drinkers contain only the water containing the vaccine. If water is still present, drain the lines before administering the vaccine.
• Ensure that all birds have been drinking during the vaccination period and that they do not have access to untreated water.
SPECIAL PRECAUTIONS FOR USE:
- Vaccinate only healthy birds.
- The vaccine should be used immediately after reconstitution - Respect the usual aseptic conditions
- Do not use equipment sterilized by chemicals.
- Do not expose the reconstituted vaccine to heat and / or direct sunlight.
- Do not freeze the reconstituted vaccine.
USE IN THE EVENT OF SEVERITY, LACTATION OR LAYING:
Do not use the vaccine in birds during laying.
POTENTIAL DRUG INTERACTIONS:
Interaction with the Newcastle disease vaccine has been tested. 7-day-old chicks were vaccinated with ATLAVAC GUMBORO PLUS and with the live ATLAVAC HB1 Newcastle disease vaccine. 14 days later, the vaccinated birds showed good protection against the pathogenic Newcastle disease virus. This shows that there is no interaction between these two vaccines. No information is available on the safety and efficacy of this vaccine when used in combination with another veterinary medicinal product. Consequently, the decision to use this vaccine before or after another veterinary medicinal product must be made on a case-by-case basis.
The presence of disinfectant and / or antiseptics in the water and equipment used for the preparation of the vaccine solution is incompatible with effective vaccination.
SIDE EFFECTS:
The vaccine used according to the recommended instructions has no apparent side effects. Nevertheless, the administration of the vaccine with 10 X the vaccine dose causes a discrete lymphocyte depletion in the purse of Fabricius from the 14th day. A repopulation of the bursa is observed on the 21st day post vaccination.
VALIDITY:
Unopened bottle: 24 months 2 hours after opening the bottle and reconstitution of the vaccine: suspension
SPECIAL PRECAUTIONS FOR STORAGE:
Store and transport the vaccine at a temperature between + 2 ° C and + 8 ° C, protect from light. Do not freeze
WITHDRAWAL PERIOD:
Zero days.
PHARMACEUTICAL FORM:
Lyophilisate for oral suspension.
Appearance: brown granulated tablet.
PRESENTATIONS:
Glass bottles of 1000 doses.
Box of 10 vials of 1000 doses.
Box of 100 vials of 1000 doses